Much of the information I present here has been taken from the Patent Docs Blog.


Genentech makes another drug used in the treatment of certain cancers, Avastin. Avastin has been used by many retinal surgeons in an "off label use" to also treat macular degeneration. The results with Avastin appear comparable to the results with Lucentis. Avastin is so much cheaper than Lucentis. It is priced at $600/vial for intravenous use, but is injected into the eye at such small doses (0.1cc) that each vial can deliver 30 doses ($20/dose).
Genentech has opposed the off-label use of Avastin. Genentech has warned ophthalmologists that there is a greater risk of stroke using Avastin. However, the increased stroke risk was seen at the therapeutic dose for cancer patients, which is 400-fold higher than the dose used to treat AMD. Recently, Genentech also reported that certain doses of Lucentis used for AMD are also associated with an increased risk of stroke.
I recently received this e-mail from a concerned retinal surgeon, and have decided to publicly share it:
US sales of Lucentis were $236 million for the 4th quarter, a 20% increase over 2007 4th quarter sales of $197 million. Total 200 8 sales were $875 million, a 7% gain over 2007 sales of $815 million.I was recently at a retina meeting in New York City, and most people Italked to use primarily Avastin. Some use Lucentis as their first-lineanti-VEGF, if their patients have secondary insurance. They generallypointed to FDA approval as their rationale. Nobody told me that, in theirexperience, Lucentis has a better safety or efficacy profile. Why haveLucentis sales been steadily rising? One might expect that, as ourexperience with Avastin grows and as long as people continue to find Avastinsafe and efficacious, Lucentis use should decline. I wonder whether a recentarticle in Retina Times offers insight. One practitioner said that he usesLucentis much more now because his office has streamlined reimbursementissues. Does the extra $80 income per dose (and the likely
need for morefrequent injections) influence practice patterns? Whatever the motivation,our burdening Medicare will ultimately mean that sometime, probably in thenot-so-distant future, Medicare cuts will result in some patients not havingaccess to valuable medical services and some of us not being able tomaintain viable practices.
- Retinal Specialist on the Avastin®/Lucentis® Controversy
- Avastin versus Lucentis: Why It Matters
- Avastin vs Lucentis: Two Drugs, One Treatment for Macular Degeneration?
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